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KMID : 0361020100530090527
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Korean Journal of Otolaryngology - Head and Neck Surgery
2010 Volume.53 No. 9 p.527 ~ p.533
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Expression and Distribution of Tumor Necrosis Factor-Alpha in Mice Cochlea Exposed to Noise
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Jo Min-Ho
Kim Chang-Ju
Koh Seung-Hyun
Nam Gi-Sung
Jeong Ha-Min
Lee Jae-Hoon
Lee Sang-Heon
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Abstract
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Background and Objectives: Recent studies have shown that inflammatory responses occur in the inner ear under various damaging conditions including noise-overstimulation.Identification of time-dependent expression patterns of pro-inflammatory cytokines during the response initiation should lead to rational therapeutic strategies that block the response and reduce the damaging sequelae.
Materials and Method: /We evaluated the time-dependent expression pattern of pro-inflammatory cytokines in noise-exposed mouse cochlea (white noise, 120 dB SPL, 3 hours) using immunohistochemistry and reverse transcriptase-polymerase chain reaction(RT-PCR).
Results: The most potent pro-inflammatory cytokine, the tumor necrosis factor-alpha (TNF-α), was up-regulated after noise exposure. Immunohistochemical analyses showed that the TNF-α expression was distinctively induced within the spiral ganglion and stria vascularis. RT-PCR showed that TNF-α was induced shortly after noise exposure and persisted upto seven days following noise exposure.
Conclusion: Taken together, acoustic trauma induces cochlear inflammation and the data suggest that TNF-α may have some role in cochlea damage that occur following noise exposure.
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KEYWORD
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Noise-induced hearing loss, Cytokines, Tumor necrosis factor-alpha
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